Hsp110-STAT3 PPI-IN-2
Hsp110-STAT3 PPI-IN-2 (compound 10b) is a Hsp110-STAT3 interaction disruptor. Hsp110-STAT3 PPI-IN-2 can be used in pulmonary arterial hypertension (PAH) related research[1].
Product Specifications
UNSPSC
12352005
Target
HSP; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hsp110-stat3-interaction-in-2.html
Smiles
OC1=CC=CC(C2=NC(C3=C(OCC4=CC=CC(C)=C4)N=C(N(C)N=C5C(F)(F)F)C5=C3)=NO2)=C1
Molecular Formula
C24H18F3N5O3
Molecular Weight
481.43
References & Citations
[1]Li M, et al. Design, synthesis and optimization of pyrazolo[3,4-b] pyridine derivatives as Hsp110-STAT3 interaction disruptors for the treatment of pulmonary arterial hypertension. Bioorg Chem. 2024 Oct 14;153:107888.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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