Hsp110-STAT3 PPI-IN-2

Hsp110-STAT3 PPI-IN-2 (compound 10b) is a Hsp110-STAT3 interaction disruptor. Hsp110-STAT3 PPI-IN-2 can be used in pulmonary arterial hypertension (PAH) related research[1].

Product Specifications

UNSPSC

12352005

Target

HSP; STAT

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hsp110-stat3-interaction-in-2.html

Smiles

OC1=CC=CC(C2=NC(C3=C(OCC4=CC=CC(C)=C4)N=C(N(C)N=C5C(F)(F)F)C5=C3)=NO2)=C1

Molecular Formula

C24H18F3N5O3

Molecular Weight

481.43

References & Citations

[1]Li M, et al. Design, synthesis and optimization of pyrazolo[3,4-b] pyridine derivatives as Hsp110-STAT3 interaction disruptors for the treatment of pulmonary arterial hypertension. Bioorg Chem. 2024 Oct 14;153:107888.