PF-4878691
Product Specifications
UNSPSC Description
PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].
Target Antigen
Apoptosis; HCV; Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-4878691.html
Purity
99.89
Solubility
DMSO : 19.23 mg/mL (ultrasonic)
Smiles
CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O
Molecular Weight
361.46
References & Citations
[1]Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.|[2]Horscroft NJ, et al. Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother. 2012 Apr;67(4):789-801.|[3]Birmachu W, et al. Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists [J]. BMC immunology, 2007, 8: 1-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100176/PF-4878691-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100176/PF-4878691-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
532959-63-0
Available Sizes
Curated Selection
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