FAUC 213

FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. FAUC 213 has less activity on D2 and D3 receptors (Kis of 3.4 μM, 5.3 μM for hD2, hD3, respectively) . FAUC 213 can cross the blood-brain barrier (BBB) . FAUC 213 exhibits atypical antipsychotic characteristic[1].

Product Specifications

CAS Number

[337972-47-1]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fauc-213.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC=C1N(CC2)CCN2CC3=NN4C=CC=CC4=C3

Molecular Formula

C18H19ClN4

Molecular Weight

326.82

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Frank Boeckler, et al. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl) . 2004 Aug;175 (1) :7-17.