(D-Arg1, D-Pro2, D-Trp7,9, L-Leu11) -Substance P (acetate)

(D-Arg1, D-Pro2, D-Trp7,9, L-Leu11) -Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation[1].

Product Specifications

CAS Number

[143077-65-0]

UNSPSC

12352209

Target

Bombesin Receptor; Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-arg1-d-pro2-d-trp7-9-l-leu11-substance-p-acetate.html

Solubility

10 mM in DMSO

Smiles

C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@@H](NC(=O)[C@@H]5N(C([C@@H](CCCNC(=N)N)N)=O)CCC5)CCCCN)=O)CCC4)CCC(N)=O)=O)CCC(N)=O)=O)C=6C=7C(NC6)=CC=CC7.xC(C)(O)=O

Molecular Formula

C75H108N20O13.xC2H4O2

Molecular Weight

1497.79 (free base)

References & Citations

[1]A Mandahl, A Bill, et al. Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11) -SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine. Acta Physiol Scand. 1984 Jan;120 (1) :27-35.