(D-Arg1, D-Pro2, D-Trp7,9, L-Leu11) -Substance P (acetate)
(D-Arg1, D-Pro2, D-Trp7,9, L-Leu11) -Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation[1].
Product Specifications
CAS Number
[143077-65-0]
UNSPSC
12352209
Target
Bombesin Receptor; Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-arg1-d-pro2-d-trp7-9-l-leu11-substance-p-acetate.html
Solubility
10 mM in DMSO
Smiles
C([C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@@H](NC(=O)[C@@H]5N(C([C@@H](CCCNC(=N)N)N)=O)CCC5)CCCCN)=O)CCC4)CCC(N)=O)=O)CCC(N)=O)=O)C=6C=7C(NC6)=CC=CC7.xC(C)(O)=O
Molecular Formula
C75H108N20O13.xC2H4O2
Molecular Weight
1497.79 (free base)
References & Citations
[1]A Mandahl, A Bill, et al. Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11) -SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine. Acta Physiol Scand. 1984 Jan;120 (1) :27-35.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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