Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400) . Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
Product Specifications
Background
Specifications
Accession Number
Q13349-1 (ITGAD) & P05107-1 (ITGB2)
Expression Region
Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2)
Host
CHO
Target
Integrin alpha D beta 2
Conjugation
Unconjugated
Tag
C-10xHis | Native
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
124.9 kDa | 80.2 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*10
Host or Source
CHO
Species
Human
Protein ID
Q13349-1 (ITGAD) & P05107-1 (ITGB2)
Preservative
Trehalose
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