Cyclo(-RGDfK)
Product Specifications
UNSPSC Description
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[2].
Target Antigen
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cyclo_-RGDfK_.html
Purity
99.48
Solubility
DMSO : 83.33 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCCCN)NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC(CN2)=O)=O)=O)N[C@@H](CCCNC(N)=N)C2=O
Molecular Weight
603.67
References & Citations
[1]Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.|[2]Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26648-26663. |Acta Biomater. 2021 Mar 9;S1742-7061(21)00152-5.|Adv Healthc Mater. 2021 May 29;e2100304.|Antioxidants (Basel). 2024 Nov 1;13(11):1339.|Bioact Mater. 2021 Jan 7;6(7):2039-2057.|Biochem Biophys Res Commun. 2023 May 23.|bioRxiv. 2024 July 13.|Bone Res. 2024 Aug 28;12(1):49.|Drug Deliv Transl Res. 2024 Mar 18.|Engineering. 8 October 2020.|Heliyon. 2024 July 02.|J Nanobiotechnology. 2024 Sep 1;22(1):528.|Mater Today Nano. 2023 Nov 10, 100432.|Mol Ther Nucleic Acids. 2021 Jan 9;23:797-810.|Res Sq. 2024 Aug 07.|Acs Biomater Sci Eng. 2023 Apr 24.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P0023/Cyclo-RGDfK-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P0023/Cyclo-RGDfK-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
161552-03-0
Available Sizes
Curated Selection
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