Rapamycin-d3

Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant[1][2].

Product Specifications

CAS Number

[392711-19-2]

Product Name Alternative

Sirolimus-d3; AY-22989-d3; NSC 226080-d3

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Autophagy; FKBP; Isotope-Labeled Compounds; mTOR

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Others; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

95.92

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C([C@@]1(O[C@@H](CC[C@H]1C)C[C@@H](/C(C)=C/C=C/C=C/[C@H](C2)C)OC([2H])([2H])[2H])O)C(N3[C@@H](CCCC3)C(O[C@@H](CC([C@@H](/C=C([C@H]([C@H](C([C@@H]2C)=O)OC)O)\C)C)=O)[C@@H](C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)=O)=O

Molecular Formula

C51H76D3NO13

Molecular Weight

917.19

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282 (18), 13395-13401.|[2]Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30 (34) :11388-97.