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SDZ 220-581 (Ammonium salt)

SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sdz-220-581-ammonium-salt.html

Purity

99.90

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=CC=C1C2=CC(C[C@H](N)C(O)=O)=CC(CP(O)(O)=O)=C2.N

Molecular Formula

C16H20ClN2O5P

Molecular Weight

386.77

Precautions

H315, H319, H335

References & Citations

[1]Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35 (6) :655-69.|[2]Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-13059A/SDZ-220-581-Ammonium-salt-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-13059A/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

CAS Number

[179411-94-0]

Available Sizes

Curated Selection

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