Recombinant Human CCL14, biotinylated

Recombinant human CCL14

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

rHuCCL14-biotin, HCC-1

Gene Name

CCL14

UniProt

Q16627

Cellular Locus

Secreted.

Reactivity

Human

Target Antigen

C-C motif chemokine 14

Target

CCL14ylated

Type

Protein

Applications

Migration assay

Dilution

Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

Form

Lyophilized

Function

Has weak activities on human monocytes and acts via receptors that also rPubMed:11085751}.

Additionnal Information

Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in cells expressing CCR1.

Storage Conditions

12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.

Specificity

CCL14ylated

Target Background

CCL14, also known as Hemofiltrate CC Chemokine-1 (HCC-1) is a small cytokine (~8kDa) that is constitutively expressed in multiple tissues. Upon processing of the N-terminal residues of full- length HCC-1 by the uPA-plasmin system, the active form of HCC-1 is a strong agonist for CCR1, CCR5, and, to a lesser extent, CCR3. CCL14 causes chemotaxis of different types of leukocytes, and its active form is a potent inhibitor of HIV entry.