Setmelanotide (TFA)
Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].
Product Specifications
Product Name Alternative
RM-493 (TFA) ; BIM-22493 (TFA) ; IRC-022493 (TFA)
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/setmelanotide-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@](C(N[C@@H]1C)=O)([H])NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O
Molecular Formula
C51H69F3N18O11S2
Molecular Weight
1231.33
References & Citations
[1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30 (10) :1892-900.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Launched
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