Purified Anti-Human CD146 Antibody[AA98]

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

MUC; cell surface glycoprotein MUC; MCAM; CD146; MUC18; cell surface glycoprotein MUC18; S-endo; MCAM; Mel-CAM; Endo-CAM; CD146; cell surface glycoprotein MUC18; MUC18; A32 antigen; CD 146; CD146 antigen; Cell surface glycoprotein P1H12; Gicerin; Melanoma adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; Melanoma associated glycoprotein MUC18; melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; MelCAM; MUC 18; S endo 1; S endo 1 endothelial associated antigen; S-endo 1 endothelial-associated antigen