Denibulin (hydrochloride)
Denibulin (MN-029) hydrochloride is an anti-angiogenic agent with anticancer activity. It can cause rapid closure of blood vessels in solid tumors and lead to dose-dependent killing of tumor cells, effectively enhancing the antitumor effects of radiation and cisplatin chemotherapy[1].
Product Specifications
CAS Number
779356-64-8
Product Name Alternative
MN-029
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/denibulin-hydrochloride.html
Smiles
O=C(OC)NC1=NC2=CC(SC3=CC=C(NC([C@@H](N)C)=O)C=C3)=CC=C2N1.Cl
Molecular Formula
C18H20ClN5O3S
Molecular Weight
421.90
References & Citations
[1]Shi W, et al. Preclinical studies of the novel vascular disrupting agent MN-029. Anticancer Res. 2005 Nov-Dec;25 (6B) :3899-904.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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