Elpipodect

Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a Ki value of 29 pM. Elpipodect can be used in research of schizophrenia[1].

Product Specifications

CAS Number

[1424371-93-6]

Product Name Alternative

MK-8189

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mk-8189.html

Purity

98.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(S1)=NN=C1CNC2=CC(OC[C@@H]3[C@@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2

Molecular Formula

C19H22N6OS

Molecular Weight

382.48

References & Citations

[1]Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66 (2) :1157-1171.