S 8849-1 (free base)

S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants[1][2].

Product Specifications

CAS Number

[104732-22-1]

Product Name Alternative

Tianeptine metabolite MC5

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-8849-1-free-base.html

Smiles

O=C(CCCCNC1C2=C(N(S(=O)(C3=CC(Cl)=CC=C31)=O)C)C=CC=C2)O

Molecular Formula

C19H21ClN2O4S

Molecular Weight

408.90

References & Citations

[1]Gaulier JM, et al. High-performance liquid chromatographic determination of tianeptine in plasma applied to pharmacokinetic studies. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748 (2) :407-14. |[2]Szafarz M, et al. Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391 (2) :185-196.