VEGFR-2/AKT-IN-2
VEGFR-2/AKT-IN-2 (Compound 5) is a VEGFR-2/AKT inhibitor (IC50: 0.061 μM for VEGFRin HepG2 cell) . VEGFR-2/AKT-IN-2 reduces total and phosphorylated AKT as well as up-regulates BAX and Caspase-3 and down-regulates Bcl-2 in cells, thereby promoting Apoptosis. VEGFR-2/AKT-IN-2 causes cell cycle arrest in S phase. VEGFR-2/AKT-IN-2 inhibits the growth of human liver tumor cells[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-akt-in-2.html
Smiles
CC1=CC=C(C=C1)C2=CSC(N/N=C3C4=NC5=CC=C(C=C5N=C4C6=C/3C=CC=C6)F)=N2
Molecular Formula
C25H16FN5S
Molecular Weight
437.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3; VEGFR2/KDR/Flk-1
Frequently Asked Questions
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