TLR7/8 agonist 11
TLR7/8 agonist 11 (compound 30) is a potent agonist of hTLR7 and hTLR8, with EC50s of 31.1 nM and 13.1 nM, respectively. TLR7/8 agonist 11 plays an important role in adaptive and innate immune responses[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-8-agonist-11.html
Smiles
NC1=NC2=CN(N=C2C(N[C@H](CO)CCC)=N1)CC3=CC=C(C=C3OC)CN(C(CC4=CC=CN=C4)C)C
Molecular Formula
C28H38N8O2
Molecular Weight
518.65
References & Citations
[1]Akash M Patel, et al. Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads. J Med Chem. 2024 Sep 12;67 (17) :15756-15779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
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