HQNO

HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

Product Specifications

CAS Number

[341-88-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hqno.html

Purity

99.19

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C1=C2C=CC=C1)=CC(CCCCCCC)=N2=O

Molecular Formula

C16H21NO2

Molecular Weight

259.34

Precautions

H302, H315, H319, H335

References & Citations

[1]N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459 (1) :141-4.|[2]Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859 (7) :482-490.