HQNO
Product Specifications
UNSPSC Description
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
Target Antigen
Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hqno.html
Purity
99.19
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
OC(C1=C2C=CC=C1)=CC(CCCCCCC)=N2=O
Molecular Weight
259.34
References & Citations
[1]N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459(1):141-4.|[2]Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130055/HQNO-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130055/HQNO-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
341-88-8
Available Sizes
Curated Selection
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