β2AR agonist 4
β2AR agonist 4 (compound A19) is a potent and selective β2-Adrenoceptor agonist with an EC50 of 3.7 pM. β2AR agonist 4 suppresses the inflammatory cytokines and leukocytes upregulation and improves lung function in COPD rat model[1].
Product Specifications
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/β2ar-agonist-4.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(OC2)=C1NC2=O)C(CNCCC3=CC=CC=C3OC)O.Cl
Molecular Formula
C19H23ClN2O5
Molecular Weight
394.85
References & Citations
[1]Xing G, et al. Discovery and Identification of Novel 5-Hydroxy-4 H-benzo [1, 4] oxazin-3-one Derivatives as Potent β2-Adrenoceptor Agonists through Structure-Based Design, Synthesis, and Biological Evaluation[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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