PROTAC ER Degrader-11
PROTAC ER Degrader-11 (Example 26-1) is a potent PROTAC ER degrader, with the IC50 of 0.66 nM. PROTAC ER Degrader-11 plays an important role in cancer research (Sturcture Note: (Blue: Cereblon ligand , Black: linker (HY-W262798); Pink: ER ligand (HY-168271) ).
Product Specifications
CAS Number
2846112-04-5
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-er-degrader-11.html
Smiles
CC(C)C[C@@H]1[C@H](C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N([C@@H]6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)C=C2)C8=CC=C(O)C=C8CC1
Molecular Formula
C43H53N5O4
Molecular Weight
703.91
References & Citations
[1] Jiangsu Hengrui Pharmaceuticals Co., Ltd, et al. Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine. World Intellectual Property Organization, WO2022206737 A1 2022-10-06
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; Estrogen receptor
Frequently Asked Questions
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