Reboxetine (mesylate)

Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM[1].

Product Specifications

CAS Number

[98769-84-7]

Product Name Alternative

FCE20124 (mesylate) ; PNU155950E (mesylate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/reboxetine-mesylate.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CS(=O)(O)=O.CCOC1=C(O[C@]([H])(C2=CC=CC=C2)[C@]3(CNCCO3)[H])C=CC=C1

Molecular Formula

C20H27NO6S

Molecular Weight

409.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Wong, E.H., et al., Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry, 2000. 47 (9) : p. 818-29.|[2]Versiani, M., et al., Reboxetine, a unique selective NRI, prevents relapse and recurrence in long-term treatment of major depressive disorder. J Clin Psychiatry, 1999. 60 (6) : p. 400-6.|[3]M Leskiewicz, et al. Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: a involvement of extracellular regulated kinase (ERK1/2) . Neurochem Int. 2013 Nov;63 (5) :354-62.