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(Z) -9-Propenyladenine

(Z) -9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

Product Specifications

CAS Number

[1464851-21-5]

Product Name Alternative

(Z) -Mutagenic Impurity of Tenofovir Disoproxil

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/_Z_-Mutagenic-Impurity-of-Tenofovir-Disoproxil.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=C2N=CN(/C=C\C)C2=NC=N1

Molecular Formula

C8H9N5

Molecular Weight

175.19

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

Available Sizes

Curated Selection

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