RL71
Product Specifications
UNSPSC Description
RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/rl71.html
Purity
97.44
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)C)=C/C3=CC(OC)=C(C(OC)=C3)OC
Molecular Weight
469.53
References & Citations
[1]RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121605/RL71-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121605/RL71-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1195795-93-7
Available Sizes
Curated Selection
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