WBS22 rabbit pAb

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11. 23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011],

Product Specifications

Background

This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011]

UniProt

O43709

Swiss Prot

O43709

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human WBS22 AA range: 144-194

Target

WBS22

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm . Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492) . Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604) . Localization is not affected by glucocorticoid treatment (PubMed:24488492) . .