DSPE-PEG-Folate, MW 3350

DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research[1][2][3].

Product Specifications

CAS Number

[1236288-25-7]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dspe-peg-folate.html

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCOP(O)(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCC(C(O)=O)NC(C1=CC=C(NCC(N=C23)=CNC3=NC(N)=NC2=O)C=C1)=O)=O.N.N.[n]

Molecular Formula

(C2H4O) nC63H104N9O15P.2H3N

Molecular Weight

3400.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Werner ME, et, al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials. 2011 Nov;32 (33) :8548-54.|[2]Li Y, et, al. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Appl Mater Interfaces. 2015 Aug 19;7 (32) :17573-81.|[3]Patlolla RR, et al. Folate-targeted etoposide-encapsulated lipid nanospheres. J Drug Target. 2008 May;16 (4) :269-75.