Cinchonine (hydrochloride)

Cinchonine hydrochloride ((8R,9S) -Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells[1].

Product Specifications

CAS Number

[5949-11-1]

Product Name Alternative

(8R,9S) -Cinchonine (hydrochloride) ; LA40221 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Apoptosis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cinchonine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O[C@@H](C1=CC=NC2=CC=CC=C12)[C@]3([H])[N@@]4C[C@H](C=C)[C@@H](CC4)C3

Molecular Formula

C19H23ClN2O

Molecular Weight

330.85

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.