Gossypol
Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Product Specifications
CAS Number
303-45-7
Product Name Alternative
BL 193
UNSPSC
12352005
Hazard Statement
H360
Target
Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gossypol.html
Purity
99.67
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12
Molecular Formula
C30H30O8
Molecular Weight
518.55
Precautions
H360
References & Citations
[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Bcl-2; Bcl-xL
Citation 01
Microb Pathog. 2024 Sep 21:106960.|Toxics. 2025 Sep 9;13 (9) :763.|Transbound Emerg Dis. 2023 Nov 11:2023:9073566.|Cell Rep. 2025 Apr 16;44 (5) :115572.|Clin Transl Med. 2021 Jun;11 (6) :e467.|Patent. US20220162561A1.|Toxicol Sci. 2025 Oct 24:kfaf149.|Nat Commun. 2023 Jun 10;14 (1) :3445.|Patent. US20220162561A1.
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