Pterosin A

Pterosin A ((2S) -Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes[1][2].

Product Specifications

CAS Number

[35910-16-8]

Product Name Alternative

(2S) -Pterosin A

UNSPSC

12352005

Target

Akt; AMPK; GLUT; GSK-3; p38 MAPK; PEPCK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pterosin-a.html

Purity

94.07

Solubility

10 mM in DMSO

Smiles

O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C

Molecular Formula

C15H20O3

Molecular Weight

248.32

References & Citations

[1]Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62 (2) :628-38.|[2]Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16 (2) :2497-516.