RTC14
RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene[1].
Product Specifications
CAS Number
414909-09-4
UNSPSC
12352005
Target
DNA/RNA Synthesis; Dystrophin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rtc14.html
Smiles
OC1=CC=C(C=C1/N=C/C2=CC=CC([N+]([O-])=O)=C2)C(C)(C)C
Molecular Formula
C17H18N2O3
Molecular Weight
298.34
References & Citations
[1]Kayali R, et al. Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy. Hum Mol Genet. 2012 Sep 15;21 (18) :4007-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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