Human Anti-Varicella Zoster Virus Antibody IgG Titer Serologic Assay Kit (gE)

Varicella-zoster virus (VZV) is a neurotropic virus belonging to the Herpesviridae family. Primary VZV infection causes chickenpox and is followed by a life-long latent infection established mainly in the cranial and dorsal root ganglia. Reactivation of the virus is often associated with shingles (herpes zoster). Glycoprotein E (gE) is one of the known glycoproteins (gB, gC, gE, gH, gI, gK, gI) of VZV that is most abundantly expressed on the surface of virus and infected cells, playing an important role in viral replication and cell-to-cell spread. The strongly immunogenic gE can provide strong IgG signal in body fluid, which makes it ideal to be developed as an antigen for analysis of IgG antibodies. gE also demonstrates high potency as a vaccine immunogen and is formulated as the single viral envelope protein that constitutes the GSK VZV recombinant subunit vaccine Shingrix®.

1. Store the unopened kit at 2-8°C upon receipt. 2. Locate the expiration date on the outer packaging and do not use reagents beyond their expiration date. 3. The opened kit should be stored according to the storage conditions listed in the Components Table. The shelf life of the opened kit is 30 days from the date of opening.

This assay kit employs a standard indirect-ELISA format, providing a rapid detection of Anti-VZV gE antibodies in Human serum by Glycoprotein E (VZV). The Kit consists of Pre-coated Glycoprotein E (VZV) Microplate, an Positive Control, an Negative Control, an HRP-Anti-Human IgG secondary antibody.