Biotinylated Anti-Human CD3 Antibody, Mouse IgG2a, Avitag™ (Clone: OKT3), premium grade

Biotinylated Anti-Human CD3 Antibody, Mouse IgG2a, Avitag (Clone: OKT3), premium grade (CDE-BV84G0) is recombinantly produced from human 293 cells (HEK293) .

Product Specifications

Background

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CAS Number

9007-83-4

Host

HEK293

Origin Species

Mouse

Target

CD3

Conjugation

Biotin-labeled

Tag

Mouse IgG2a & Avi | Mouse kappa

Stability

2-8°C for 12 months under sterile conditions; -70°C for 24 months. For long term storage, the product should be stored at liquid state at -70°C.

Endotoxin

0.002 EU per μg

Purity

0.95

Bioactivity

Immobilized Human CD3E&CD3G Heterodimer Protein, His Tag&Tag Free (Cat. No. CDG-H52W5) at 1 μg/mL (100 μL/well) can bind Biotinylated Anti-Human CD3 Antibody, Mouse IgG2a,Avitag (Clone: OKT3), premium grade (Cat. No. CDE-BV84G0) with a linear range of 0.3-10 ng/mL (QC tested).