Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AS106) (Beta & Gamma Specific)

The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with Spike RBD. <strong>The antibody is specific against the Beta (B.1.351) and Gamma (P.1) variant of SARS-CoV-2, and has no binding with the spike RBD of the wild type virus, the Alpha (B.1.1.7) variant, the Delta (B.1.617.2) variant and the Omicron (B.1.1.529, BA.2) variant.</strong>

Product Specifications

Background

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

CAS Number

9007-83-4

Host

Hybridoma

Origin Species

Mouse

Target

Spike RBD

Conjugation

Unconjugated

Tag

Human IgG | Human Kappa

Stability

● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions. Please avoid repeated freeze-thaw cycles.

Purity

95%

Bioactivity

Immobilized SARS-CoV-2 Spike RBD protein B.1.1.529/Omicron (Cat. No. SPD-C522e), BA.2/Omicron ( Cat. No. SPD-C522g), BA.2.12.1/Omicron (Cat. No. SPD-C522q) and BA.3/Omicron (Cat. No. SPD-C522i) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AS106) (Beta & Gamma Specific) (Cat. No. SPD-M416) with a linear range of 0.05-1.56 ng/mL. The antibody does not bind Spike RBD protein BA.4&BA.5/Omicron (Cat. No. SPD-C522r), Spike protein BA.4/Omicron (Cat. No. SPN-C5229) and BA.5/Omicron (Cat. No. SPN-C522e) (Routinely tested).