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Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (MALS verified)

Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AM122) (S1N-VM226) is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 Protein. <strong>As verified in competitive ELISA-based and pseudovirus-based neutralization assay, this chimeric monoclonal can potently neutralize all SARS-CoV-2 Variants of Concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2) . </strong>

Product Specifications

Background

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Host

HEK293

Origin Species

Mouse

Target

Spike RBD

Conjugation

Biotin-labeled

Tag

Mouse IgG1 & Avi | Mouse Kappa

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles.

Purity

95%

Bioactivity

Immobilized SARS-CoV-2 Spike Protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) at 2 μg/mL (100 μL/well) can bind Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AM122) (Cat. No. S1N-VM226) with a linear range of 0.2-13 ng/mL (Routinely  tested)

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

25ug*1

Product Datasheet

Https://www.acrobiosystems.com/static/main/products/pdf/ds/S1N-VM226.pdf

Species

Mouse

CAS Number

9007-83-4

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