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Tiagabine-d4 (hydrochloride)

Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride. Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

Product Specifications

Product Name Alternative

NO050328-d4 (hydrochloride) ; NO328-d4 (hydrochloride) ; TGB-d4 (hydrochloride)

UNSPSC

12352005

Target

GABA Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(C1C([2H])N(CC/C=C(C2=C(C)C=CS2)/C3=C(C)C=CS3)C([2H])C([2H])C1[2H])O.Cl

Molecular Formula

C20H22D4ClNO2S2

Molecular Weight

416.03

References & Citations

[1]Braestrup C, et al. (R) -N-[4,4-bis (3-methyl-2-thienyl) but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54 (2) :639-47.|[2]Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40 (3) : p. 32-40.|[3]Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50 (2) : p. 365-70.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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