Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade (HEK)
Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade (CDE-M120a) is recombinantly produced from human 293 cells (HEK293) .
Product Specifications
Background
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
CAS Number
9007-83-4
Host
HEK293
Origin Species
Mouse
Target
CD3
Conjugation
Unconjugated
Tag
Mouse IgG2a | Mouse kappa
Stability
2-8°C for 12 months under sterile conditions; -70°C for 24 months. For long term storage, the product should be stored at liquid state at -70°C.
Endotoxin
0.002 EU per μg
Purity
0.95
Format
Liquid
Buffer
PBS, pH7.4
Additives
Trehalose
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
500ug*2
Host or Source
HEK293
Species
Mouse
Preservative
Trehalose
Curated Selection
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