PolQi1
Product Specifications
UNSPSC Description
PolQi1 is a Polϴ (polymerase theta) inhibitor. PolQi1 targets the polymerase domain of the enzyme[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polqi1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C1=C(C(Cl)=C(C=C1)F)F)C([C@H]2N(C3=CC(C(F)(F)F)=CC(C)=N3)C(NC2)=O)=O
Molecular Weight
448.77
References & Citations
[1]Wimberger S, et al. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing. Nat Commun. 2023 Aug 14;14(1):4761.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159078/PolQi1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159078/PolQi1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2607139-80-8
Available Sizes
Curated Selection
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