TRPV1 antagonist 6
TRPV1 antagonist 6 (compound 51) is a mode-selective antagonist for transient receptor potential vanilloid member 1 (TRPV1), which shows antagonism with IC50 of 2.85 nM to capsaicin activation and 28.48 % inhibition against proton activation at a 3 µM concentration[1].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpv1-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)C1=NN(C(CNC(NC2=CC=CC(N3CCO)=C2C=CC3=O)=O)=C1)C4=CC=CC(Cl)=C4
Molecular Formula
C26H28ClN5O3
Molecular Weight
493.99
References & Citations
[1]Zuo D, et al., Discovery of N- (1- (2-hydroxyethyl) quinolin-2-one) -N'- (1-phenyl-1H-pyrazol-5-yl) methyl) urea as Mode-Selective TRPV1 antagonist. Bioorg Med Chem Lett. 2024 Feb 13;101:129656
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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