(7S) -BAY-593

(7S) -BAY-593 is the S-enantiomer of BAY-593 (HY-161573) . BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity[1].

Product Specifications

CAS Number

[2413068-25-2]

UNSPSC

12352005

Target

GGTase; YAP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7s-bay-593.html

Purity

99.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CCC2(CCNC[C@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4

Molecular Formula

C26H31F3N2O3

Molecular Weight

476.53

References & Citations

[1]Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456 (24) 00087-4.