Cynomolgus CD6 Protein, His Tag (MALS verified)

CD6 (Cluster of Differentiation 6) is a transmembrane protein primarily expressed on T-lymphocytes and certain other immune cells. Structurally, it is characterized by three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule (ALCAM) . Functionally, CD6 is critical for the continuation of T cell activation and exhibits scavenger receptor activity. Aberrant CD6 function is associated with diseases such as Multiple Sclerosis. Its paralog is DMBT1.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 55-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

XP_005577746.1

Expression Region

His 18 - Leu 399

Host

HEK293

Target

CD6

Conjugation

Unconjugated

Tag

C-10xHis

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human ALCAM, Fc Tag (Cat. No. CD6-H5259) at 5 μg/mL (100 μL/well) can bind Cynomolgus CD6 Protein, His Tag (Cat. No. CD6-C52H3) with a linear range of 0.02-0.625 μg/mL (QC tested).