Human MICA (24-202) Protein, His Tag (MALS verified)
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
Product Specifications
Background
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 31-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q29983-1
Expression Region
Glu 24 - Arg 202
Host
HEK293
Target
MICA
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Human MICA (24-202) Protein, His Tag (Cat. No. MIA-H52H7) at 10 μg/mL (100 μL/well) can bind Human NKG2D Protein, Fc Tag (Cat. No. NKD-H5265) with a linear range of 0.078-2.5 μg/mL (QC tested).
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
22.8 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
HEK293
Species
Human
Protein ID
Q29983-1
Preservative
Trehalose
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