SARS-CoV-2 Spike NTD Protein, His Tag (XBB.1/Omicron) (MALS verified)
SARS-CoV-2 Spike NTD Protein, His Tag (XBB.1/Omicron) (SPD-C5245) is expressed from human 293 cells (HEK293) . It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1 (T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V) ) . The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: XBB.1) .
Product Specifications
Background
It's been reported that coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.5 kDa. The protein migrates as 47-64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
QHD43416.1 (T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V)
Expression Region
Ser 13 - Leu 303
Host
HEK293
Target
Spike NTD
Conjugation
Unconjugated
Tag
C-10xHis
Source
SARS-CoV-2
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized SARS-CoV-2 Spike NTD Protein, His Tag (XBB.1/Omicron) (Cat. No. SPD-C5245) at 1 μg/mL (100 μL/well) can bind Anti-SARS-CoV-2 Spike NTD Antibody, Chimeric mAb, Human IgG1 (AM121) (Cat. No. SPD-M121) with a linear range of 0.1-2 ng/mL (QC tested).
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
34.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/SPD-C5245.pdf
Species
SARS-CoV-2
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