Human MANF Protein, His Tag (MALS verified)
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.
Product Specifications
Background
Specifications
Accession Number
P55145
Expression Region
Leu 25 - Leu 182
Host
HEK293
Target
MANF
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
Endotoxin
0.1 EU per μg
Purity
95%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
20.0 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
20ug*1
Host or Source
HEK293
Species
Human
Protein ID
P55145
Preservative
Trehalose
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