Biotinylated Human LYPD1 / PHTS Protein, His, Avitag™

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 14.1 kDa. The protein migrates as 18-22 kDa and 35-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q8N2G4-1

Expression Region

Leu 21 - Gly 115

Host

HEK293

Target

LYPD1

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Biotinylated Human LYPD1 Protein, His,Avitag (Cat. No. LY1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Anti-LYPD1 antibody with a linear range of 0.008-0.125 μg/mL (QC tested).