Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
Human Mesothelin (391-598), Fc Tag (MSN-H5267) is expressed from human 293 cells (HEK293) . It contains AA Ser 391 - Ser 598 (Accession # AAH09272.1) .
Product Specifications
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Specifications
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 49.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
AAH09272.1
Expression Region
Ser 391 - Ser 598
Host
HEK293
Target
Mesothelin
Conjugation
Unconjugated
Tag
N-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.2 EU per μg
Purity
95%
Bioactivity
Immobilized Human Mesothelin (391-598), Fc Tag (Cat. No. MSN-H5267) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human MSLN Antibody, Human IgG1 with a linear range of 0.156-5 μg/mL (QC tested).
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
49.6 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/MSN-H5267.pdf
Species
Human
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