Cynomolgus CD79A Protein, His Tag

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79a), also known as CD79α, IgM-α, Ig-α and mb-1, which is a signaling component of the preB cell receptor (preBCR) . Covalently linked CD79a and CD79b heterodimer constitutes the B cell antigen receptor (BCR) with membrane immunoglobulin (mIg) in a non-covalent association. CD79a is required in cooperation with CD79b for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR), leading to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.4 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

XP_045235481.1

Expression Region

Leu 33 - Arg 142

Host

HEK293

Target

CD79A

Conjugation

Unconjugated

Tag

C-10xHis

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.