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Human HTT Protein, MBP, His Tag (MALS verified)

Huntingtin is the protein coded for by the HTT gene. Autosomal dominant mutation in the Huntingtin (Htt) protein is the cause of Huntington’s Disease (HD) . In HD, the polyglutamine (polyQ) domain in the N-terminal sequenceof the protein is expanded beyond a threshold of 36 glutamines. mutant polyQ expansion strongly correlates in an inverse manner to disease age of onset.

Product Specifications

Background

Huntingtin is the protein coded for by the HTT gene. Autosomal dominant mutation in the Huntingtin (Htt) protein is the cause of Huntington’s Disease (HD) . In HD, the polyglutamine (polyQ) domain in the N-terminal sequenceof the protein is expanded beyond a threshold of 36 glutamines. mutant polyQ expansion strongly correlates in an inverse manner to disease age of onset.

Specifications

This protein carries a MBP tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-63 kDa under reducing (R) condition (SDS-PAGE) .

Accession Number

P42858-1

Expression Region

Met 1 - Glu 82

Host

E. coli

Target

HTT

Conjugation

Unconjugated

Tag

N-MBP & C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Format

Powder

Buffer

20 mM HEPES, 150 mM NaCl, pH7.5

Additives

Trehalose

Molecular Weight

52.7 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

500ug*1

Product Datasheet

https://console.acrobiosystems.com/public/product/pdf/ds/HTT-H51M5.pdf

Host or Source

E. coli

Species

Human

Protein ID

P42858-1

Preservative

Trehalose

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