Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Product Specifications
Background
Specifications
Accession Number
NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5)
Expression Region
Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5)
Host
HEK293
Target
Integrin alpha V beta 5
Conjugation
Unconjugated
Tag
C-10xHis | Native
Source
Rat
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
112.3 kDa | 81.7 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
HEK293
Species
Rat
Protein ID
NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5)
Preservative
Trehalose
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