Mouse IL-17C Protein, His Tag
Interleukin-17C (IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL‑17C binds to IL‑17 RE with high affinity and to IL‑17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.
Product Specifications
Background
Specifications
Accession Number
Q8K4C5-1
Expression Region
Asp 17 - Gln 194
Host
HEK293
Target
IL-17C
Conjugation
Unconjugated
Tag
C-10xHis
Source
Mouse
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Format
Powder
Buffer
PBS, 0.5 M Arginine, pH7.4
Additives
Trehalose
Molecular Weight
21.7 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Mouse
Protein ID
Q8K4C5-1
Preservative
Trehalose
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