Human KIR2DL4 / CD158d Protein, Fc Tag
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) -AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP) -1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.
Product Specifications
Background
Specifications
Accession Number
Q99706-1
Expression Region
His 24 - His 242
Host
HEK293
Target
KIR2DL4
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
50.5 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
Q99706-1
Preservative
Trehalose
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
